PiCSO in ACS: Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI
Multi-center study showed that PiCSO therapy is associated with a lower infarct size at 5 days after anterior STEMI in a propensity score-matched population. Read more
OxAMI-PiCSO: Oxford Acute Myocardial Infarction – Pressure-controlled Intermittent Coronary Sinus Occlusion
Aiming to further demonstrate efficacy of PiCSO therapy in high-IMR STEMI patients. Read more
PiCSO-AMI-I: Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infraction
Recruiting randomized controlled study (RCT) demonstrated of PiCSO therapy during PCI compared to standard PCI in STEMI patients. Read more
How could PiCSO interventional trans-coronary sinus technology reduce heart failure post-STEMI? Watch video
Miracor Latest experience with PiCSO in STEMI patients Watch video
Miracor PiCSO therapy to reduce infarct size & clear microcirculation in STEMI patients Watch video
Scarsini R, Terentes-Printzios D, Shanmuganathan M, Kotronias RA, Borlotti A, Marin F, Langrish J, Lucking A, Ribichini F; Oxford Acute Myocardial Infarction (OxAMI) Study, Kharbanda R, Ferreira VM, Channon KM, De Maria GL, Banning AP. Pressure-controlled intermittent coronary sinus occlusion improves the vasodilatory microvascular capacity and reduces myocardial injury in patients with STEMI. Catheter Cardiovasc Interv. 2021 May 29.
Egred M, Bagnall A, Spyridopoulos I, et al. Effect of Pressure-controlled intermittent Coronary Sinus Occlusion (PiCSO) on infarct size in anterior STEMI: PiCSO in ACS study. Int J Cardiol Heart Vasc. 2020;28:100526. Published 2020 May 15.
De Maria GL, Alkhalil M, Borlotti A, et al. Index of microcirculatory resistance-guided therapy with pressure-controlled intermittent coronary sinus occlusion improves coronary microvascular function and reduces infarct size in patients with ST-elevation myocardial infarction: the Oxford Acute Myocardial Infarction – Pressure-controlled Intermittent Coronary Sinus Occlusion study (OxAMI-PiCSO study). EuroIntervention. 2018;14(3):e352-e359. Published 2018 Jun 8.
Van de Hoef TP, Nijveldt R, van der Ent M, et al. Pressure-controlled intermittent coronary sinus occlusion (PiCSO) in acute ST-segment elevation myocardial infarction: results of the Prepare RAMSES safety and feasibility study. EuroIntervention. 2015;11(1):37-44.
Van de Hoef TP, Nolte F, Delewi R, et al. Intracoronary hemodynamic effects of pressure-controlled intermittent coronary sinus occlusion (PiCSO): results from the First-In-Man Prepare PiCSO Study. J Interv Cardiol. 2012;25(6):549-556.
Stone GW, Selker HP, Thiele H, et al. Relationship Between Infarct Size and Outcomes Following Primary PCI: Patient-Level Analysis From 10 Randomized Trials. J Am Coll Cardiol. 2016;67(14):1674-1683.
Mohl, W., D. Milasinovic, and D.P. Faxon. Amending a dogma. EuroIntervention, 2018. 14(12): p. e1258-e1261.
De Maria GL, Kassimis G, Raina T, et al. Reconsidering the back door approach by targeting the coronary sinus in ischaemic heart disease. Heart. 2016;102(16):1263-1269.
Faxon DP. Coronary venous interventions: failed strategy or inadequately explored? Circ Cardiovasc Interv. 2015;8(5):e002743.
Khattab AA, Stieger S, Kamat PJ, et al. Effect of pressure-controlled intermittent coronary sinus occlusion (PiCSO) on myocardial ischaemia and reperfusion in a closed-chest porcine model. EuroIntervention. 2013;9(3):398-406.
Mohl W, Komamura K, Kasahara H, et al. Myocardial protection via the coronary sinus. Circ J. 2008;72(4):526-533.
Weigel G, Kajgana I, Bergmeister H, et al. Beck and back: a paradigm change in coronary sinus interventions—pulsatile stretch on intact coronary venous endothelium. J Thorac Cardiovasc Surg. 2007;133(6):1581-1587.
Kasahara H, Komamura K, Glogar D, et al. Do long term effects after PiCSO endorse the potential of cardiac regeneration after acute myocardial infarction?. Wien Klin Wochenschr. 2007;119(11-12 Suppl 1):23-26.
Mohl W, Kajgana I, Bergmeister H, et al. Intermittent pressure elevation of the coronary venous system as a method to protect ischemic myocardium. Interact Cardiovasc Thorac Surg. 2005;4(1):66-69.
Syeda B, Schukro C, Heinze G, et al. The salvage potential of coronary sinus interventions: meta-analysis and pathophysiologic consequences. J Thorac Cardiovasc Surg. 2004;127(6):1703-1712.
Xie F, Qian L, Goldsweig A, et al. Event-Free Survival Following Successful Percutaneous Intervention in Acute Myocardial Infarction Depends on Microvascular Perfusion. Circ Cardiovasc Imaging. 2020;13(6):e010091.
Gdowski MA, Murthy VL, Doering M, et al. Association of Isolated Coronary Microvascular Dysfunction With Mortality and Major Adverse Cardiac Events: A Systematic Review and Meta-Analysis of Aggregate Data. J Am Heart Assoc. 2020;9(9):e014954.
de Waha S, Patel MR, Granger CB, et al. Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J. 2017;38(47):3502-3510.
