PiCSO clinical studies have demonstrated statistically significant improvements in:
- Infarct size reduction as a percent of left ventricular mass
- Index of microcirculatory resistance (IMR) 24h post procedure
De Maria GL, Alkhalil M, Borlotti A, et al. Index of microcirculatory resistance-guided therapy with pressure-controlled intermittent coronary sinus occlusion improves coronary microvascular function and reduces infarct size in patients with ST-elevation myocardial infarction: the Oxford Acute Myocardial Infarction – Pressure-controlled Intermittent Coronary Sinus Occlusion study (OxAMI-PiCSO study). EuroIntervention. 2018;14(3):e352-e359. Published 2018 Jun 8.
de Waha S, Patel MR, Granger CB, et al. Relationship between microvascular obstruction and adverse events following primary percutaneous coronary intervention for ST-segment elevation myocardial infarction: an individual patient data pooled analysis from seven randomized trials. Eur Heart J. 2017;38(47):3502-3510.